9-35--5889-[3'4':67]-[23-][13]-65- NEW 9-35-DIMETHOXYPHENYL-588a9-TETRAHYDROFURO[3'4':67]NAPHTHO-[23-d][13]DIOXOL-65aH-ONE COMPOUNDS A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

• Main Authors: ATASSI GHANEM, MERESSE PHILIPPE, RENARD PIERRE, PIERRE ALAIN, MONNERET CLAUDE, PFEIFFER BRUNO, BERTOUNESQUE EMMANUEL
• Format: Patent
• Language: English; Korean
• Published: 15.05.2001
• Edition: 7
• Subjects: APPARATUS THEREFOR; CHEMISTRY; DERIVATIVES THEREOF; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

PURPOSE: Provided are 9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-(3',4':6,7)naphtho(2,3-d)(1,3)dioxol-6(5aH)-one compounds which are natural products useful for the treatment of cancer, their preparation method, and a pharmaceutical composition containing them. CONSTITUTION: 9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-(3',4':6,7)naphtho(2,3-d)(1,3)dioxol-6(5aH)-one compound is represented by the formula(I), wherein wherein:R represents:a group of formula(I): wherein X, Y and W are as defined in the description,or a group of formula(II) of -A-G: wherein:A represents a single bond or an optionally substituted alkylene chain,G represents a group selected from hydrogen, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -OR2, -O-T1-NR3R4, -O-T1-NR2-T'1-NR3R4, -NR3R4, -NR2-T1-NR3R4, -NR2-T1-OR5, -NR2-T1-CO2R6, -NR2-T1-C(O)R6, -C(O)-NR3R4, -C(O)-NR2-T2, -O-C(O)T2, -O-C(S)-T2, -NR2-C(O)-T2, -NR2-C(S)-T2, -O-C(O)-O-T2, -O-C(O)-NR2-T2, -O-C(S)-O-T2, -O-C(S)-NR2-T2, -NR2-C(O)-O-T2, -NR2-C(O)-NR-T2, -NR2-C(S)-O-T2, -NR2-C(S)-NR6-T2 and -NR2-SO2-T3, wherein R2, R3, R4, R5, R6, T1, T'1, T2 and T3 are as defined in the description,R1 represents a group selected from hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, heterocycloalkylcarbonyl, alkylsulphonyl, arylsulphonyl, arylalkylsulphonyl, phosphono, aryloxycarbonyl, alkoxycarbonyl and arylalkoxycarbonyl,its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base.Medicinal products containing the same which are useful in the treatment of cancer. 본 발명은 하기 화학식(I)의 화합물, 이들의 이성질체 및 이들과 약제학적으로 허용되는 산 또는 염기와의 부가염에 관한 것이다: 상기식에서, R은 - 하기 화학식(i)의 기, 또는 (상기식에서, X, Y 및 W는 상세한 설명에서 정의한 바와 같다) - 하기 화학식(ii)의 기이고; - A - G(ii) (상기식에서, A는 단일 결합, 치환되거나 치환되지 않은 알킬렌 사슬이고, G는 수소, 시클로알킬, 헤테로시클로알킬, 아릴, 헤테로아릴, -OR, -O-T-NRR, -O-T-NR-T'-NRR, -NRR, -NR-T-NRR, -NR-T-OR, -NR-T-COR, -NR-T-C(O)R, -C(O)-NRR, -C(O)-NR-T, -O-C(O)-T, -O-C(S)-T, -NR-C(O)-T, -NR-C(S)-T, -O-C(O)-O-T, -O-C(O)-NR-T, -O-C(S)-O-T, -O-C(S)-NR-T, -NR-C(O)-O-T, -NR-C(O)-NR-T, -NR-C(S)-O-T, -NR-C(S)-NR-T및 -NR-SO-T(여기에서, R, R, R, R, R, T, T', T및 T는 상세한 설명에서 정의한 바와 같다)이다); R은 수소, 알킬, 아릴, 아릴알킬, 헤테로아릴, 헤테로아릴알킬, 알킬카르보닐, 아릴카르보닐, 아릴알킬카르보닐, 헤테로시클로알킬카르보닐, 알킬술포닐, 아릴 술포닐, 아릴알킬술포닐, 포스포노, 아릴옥시카르보닐, 알콕시카르보닐 및 아릴알콕시카르보닐로부터 선택된 기이다