ISOLATED PEPTIDES WHICH COMPLEX WITH HLA-CW16 MOLECULES, AND USES THEREOF

• Main Authors: DEPLAEN ETIENNE, VAN DER BRUGGEN PIERRE, BOON PALLEUR THIERRY
• Format: Patent
• Language: English
• Published: 26.06.2000
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PURPOSE: Peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells are provided. CONSTITUTION: The isolated peptide consists of: amino acid sequence Xaa Ile (Xaa)4 Arg(Xaa)2 Tyr Xaa wherein a first Xaa is from 0-3 amino acids in length, a fourth Xaa is 0-3 amino acids in length, and a first and fourth Xaa are no more than 3 amino acids in total, each Xaa is any amino acid, and the peptide binds to an HLA-Cw16 molecule. Method for provoking proliferation of a cytolytic T cell specific for a complex of a peptide and an HLA-Cw16 molecule, comprises contacting a T cell containing sample with a cell which present complexes of an HLA-Cw16 molecule and the peptide on its surface, under conditions favoring recognition of the complex by a T cell, followed by proliferation.