SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS

• Main Authors: THOMPSON, MERVYN, HARLING, JOHN, DAVID, ORLEK, BARRY, SIDNEY
• Format: Patent
• Language: English; Korean
• Published: 25.03.2000
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PURPOSE: Substituted benzamido-heterocyclic compounds and use thereof are described which are useful as anticonvulsants. CONSTITUTION: The substituted benzamido-heterocyclic compounds of general formula (I) having an alkoxy substituent at the C2 position of the benzamido group and various substituents at positions C4 and C5, being optionally substituted on the N atom of the heterocyclic system, and where the unsaturated ring of the heterocyclic system is a 5, 6, 7 or 8-membered ring are described. Also to the use of these compounds as anticonvulsants in certain medical conditions, and to processes for making them are described. In formula, R1 is C1-6 alkylO-; R2 is H, halogen, CN, N3, CF3, benzoyl, C1-6 alkylS, or C1-6 alkylSO2; R3 is H, halogen, NO2, CN, C1-6 alkenyl, or, phenyl-C1-4alkyl-; R4 is H, C1-6 alkyl or C1-6 alkenyl; n,p are 1-4. 본 발명은 벤즈아미도기의 C2 위치에 알콕시 치환체와, C4 및 C5 위치에 다양한 치환체가 있고, 헤테로시클릭계의 N 원자가 임의로 치환되고 헤테로시클릭계의 불포화 고리가 5, 6, 7 또는 8원 고리인 하기 화학식 (Ⅰ)의 치환된 벤즈아미도-헤테로시클릭 화합물에 관한 것이다. 또한 본 발명은 특정 의학적 상태에 있어서 항경련제로서의 이들 화합물의 용도와 그 제조 방법에 관한 것이다. 〈화학식Ⅰ〉