PROCESS FOR PREPARING HIGH PURITY 1-BROMOETHYL CARBOXYLATE

PURPOSE: The 1-bromoethyl carboxylate is prepared to high purity which has high converting rate and a good industrial utilization. CONSTITUTION: 1 Equivalent weight of vinyl carboxylates(formula II; R is methyl or tert-butyl group) are reacted with 0.5- 1.5 equivalent weight of hydrogen bromide gas...

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Bibliographic Details
Main Authors RYU, EUI SANG, KIM, HONG SEON, KIM, WAN JU, LEE, KWAN SUN
Format Patent
LanguageEnglish
Korean
Published 15.03.2000
Edition7
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE: The 1-bromoethyl carboxylate is prepared to high purity which has high converting rate and a good industrial utilization. CONSTITUTION: 1 Equivalent weight of vinyl carboxylates(formula II; R is methyl or tert-butyl group) are reacted with 0.5- 1.5 equivalent weight of hydrogen bromide gas at -78- 50 degree C to give 1-bromoethyl carboxylate(formula I). Thus, 425 g of hydrogen bromide gas obtained from PBr3 and H2O is added in 431 g of vinyl acetate at -10 degree C for 2 hours, left at room temperature for 2 hours. Obtained compound is distilled at 40 degree C, depressurized to give 836 g of title compound. 본 발명은 세팔로스포린계 항생제의 프로드럭의 제조에 유용한 하기 화학식 (1)의 1-브로모에틸 카르복실레이트의 신규 제조 방법에 관한 것이다. 상기식에서, R 은 메틸 또는 t-부틸기를 나타낸다.
Bibliography:Application Number: KR19980035649