PYRIDOCARBAZOL DERIVATIVE HAVING CGMP-PDE INHIBITING ACTIVITY

PURPOSE: The invention relates to new pyridocarbazole derivatives having highly selective cGMP-phosphodiesterase inhibiting activity. Conventional therapeutic agents require sufficient attention because the agents have possibilities of affecting badly to trachea and lung when they are administered f...

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Main Authors KIKUTSI AKIRA, NISIZIMA KAZMI, SEUDO DOSIYUKI, OHASHI MASAYUKI, YANAGIBASHI KATSTOSHI, NOTS DATSTO, NISHIDA HIDEMITS
Format Patent
LanguageEnglish
Korean
Published 25.02.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:PURPOSE: The invention relates to new pyridocarbazole derivatives having highly selective cGMP-phosphodiesterase inhibiting activity. Conventional therapeutic agents require sufficient attention because the agents have possibilities of affecting badly to trachea and lung when they are administered for long term. CONSTITUTION: The invention relates to new pyridocarbazole derivatives having highly selective cGMP-phosphodiesterase inhibiting activity, producing methods thereof, effective preventive and therapeutic agents for diseases to which cGMP-PDE inhibiting activities are effective, hypertension or ischemitic heart failure, containing at least one of the derivatives as effective component and effective, and intermediates useful for producing pyridocarbazole derivatives. 본 발명은 고선택적 사이클릭 GMP-포스포디에스테라제(이하, cGMP-PDE로 약칭함) 저해작용을 가진 신규한 피리도카르바졸 유도체, 이들의 제조방법, 이 유도체 중 적어도 한가지를 유효성분으로서 함유하는 것을 특징으로 하는, 폐고혈압증, 허혈성 심질환, 또는 cGMP-PDE 저해작용이 효과적인 질환의 예방 및/또는 치료제, 및 피리도카르바졸 유도체를 제조하기 위해 유용한 중간제에 관한 것이다. [화학식 I]
Bibliography:Application Number: KR19980709067