ANTI-HELICOBACTER PYLORI COMPOSITIONS CONTAINING 1-METHYLCARBAPENEM DERIVATIVES AS THE ACTIVE INGREDIENT

• Main Authors: OHYA, SATOSHI, KAWAMOTO, ISAO, UTSUI, YUKIO
• Format: Patent
• Language: English; Korean
• Published: 25.01.2000
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PURPOSE: This concerns a method for manufacturing 1-methylcarbapenem derivatives, an anti-helicobacter pylori composition containing an ester as an active ingredient, and an anti-helicobacter pylori medicine and a method for administering the pharmaceutically effective amount to a warm blood animal. CONSTITUTION: 1-methylcarbapenem derivatives of general formula (I) and pharmacologically acceptable salts and esters thereof, useful as the active ingredient of anti-helicobacter pylori compositions (such as therapeutic or preventive agents for Helicobacter piloriinfections, particularly the therapeutic agents). In said formula, R1 is (IIa), (IIb), (IIc) or (IId), wherein R2 is hydrogen or alkyl; and R3 is hydrogen or alkyl. 본 발명은 항 헬리코박터 피롤리 조성물의 활성 성분으로써 유용한, 일반식 (I) 의 1-메틸카르바페넴 유도체 및 그의 약리상 허용되는 염 및 에스테르 (헬리코박터 피롤리 감염에 대한 치료제 또는 예방약 등, 특히 치료제) 에 관한 것이다. 상기 식에서, R은 (IIa), (IIb), (IIc), 또는 (IId) 이고, R는 수소 또는 알킬; 그리고 R는 수소 또는 알킬이다.