OXAZOLONE DERIVATIVES AND THEIR USE AS ANTI-HELICOBACTER PYLORI AGENT

• Main Authors: KANAMARU TSUNEO, NAKAO MASAFUMI, TAWADA HIROYUKI, KAMIYAMA KEIJI
• Format: Patent
• Language: English; Korean
• Published: 25.01.2000
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPIRITS; VINEGAR; WINE

PURPOSE: Provided is an anti-Helicobacter pylori agent comprising an oxazoline-4-one derivative which is highly specific to Helicobacter genus bacteria and has excellent antibacterial activity, whereby useful as a therapeutic agent for gastric and duodenal ulcer and the like. CONSTITUTION: An anti-Helicobacter pylori agent comprising a compound represented by formula (I) is provided wherein: A represents an aromatic ring group which may be substituted; R¬1 and R¬2, whether identical or not, each represents a hydrogen atom or a hydrocarbon group which is substituted; R¬3 and R¬4, whether identical or not, each represents a hydrogen atom, a hydrocarbon group which is substituted, an acyl group, a carbamoyl group which is substituted, or a carboxyl group which is esterified; or a salt thereof. 본 발명은 하기 화학식으로 표현되는 화합물 또는 그의 염을 함유하는 항-헬리코박터 파일로리 제제에 관한 것이다: (식중, A 는 치환가능한 방향족 고리기를 나타내고; R및 R는, 동일하거나 상이하고, 각각 수소 원자 또는 치환가능한 탄화수소기를 나타내고; R및 R는 동일하거나 상이할 수 있으며, 각각 수소 원자, 치환가능한 탄화수소기, 아실기, 치환가능한 카르바모일기, 또는 에스테르화될 수 있는 카르복실기를 나타낸다).