Ricin vaccine with removed toxicity and improved solubility and expression level and preparing method thereof

• Main Authors: SONG DONG HYUN, HONG SUNG HYUN, LEE YONG JIN, YUN HYEONGSEOK, CHO HAE EUN, YU CHI HO, SONG YOUNG JO, HUR GYEUNG HAENG, CHOI JUNYOUNG, KIM NAYOUNG
• Format: Patent
• Language: English; Korean
• Published: 17.05.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a ricin vaccine that eliminates toxicity and improves solubility and expression level, and a method for manufacturing the same. In order to solve the above problem, according to one aspect of the present invention, the present invention provides the ricin vaccine comprising an RTA protein in which amino acids 1 to 4 and amino acids 189 to 263 have been removed from the amino acid sequence shown in SEQ ID NO: 5. 본 발명은 독성이 제거되고 용해성과 발현량이 향상된 리신 백신 및 이의 제조방법에 관한 것이다.