Composition for Preventing or Treating Benign Prostatic Hyperplasia Comprising High Maysin Corn Silk Extract

• Main Authors: KANG HYUN JOONG, KIM WOOKYOUNG, KIM SUN RIM, KIM MYUNG HWAN
• Format: Patent
• Language: English; Korean
• Published: 14.03.2019
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a novel use of maysin, which is for preventing or treating benign prostatic hyperplasia. A composition containing maysin or a corn silk extract as an active component inhibits the expression of 5α reductase 2 mRNA in prostate to reduce a concentration of 5α-R2, thereby inhibiting a conversion of testosterone to DHT to inhibit benign prostatic hyperplasia induced by testosterone. Therefore, the composition can be usefully used for preventing or treating benign prostatic hyperplasia. 본 발명은 메이신의 새로운 용도인 전립선 비대증의 예방 또는 치료용도에 관한 것으로, 메이신 또는 옥수수수염 추출물을 유효성분으로 함유하는 조성물은 전립선에서 5α 리덕타제 2(5α reductase 2) mRNA 발현을 억제하여 5α-R2 농도를 감소시켜 테스토스테론이 DHT로 전환되는 것을 억제함으로써 테스토스테론으로 유발된 전립선비대를 억제시킬 수 있어 전립선 비대증의 예방 또는 치료에 유용하게 사용할 수 있다.