Novel benzoxazole or benzothiazole derivatives preparation method thereof and pharmaceutical composition for use in preventing or treating cancer containing the same as an active ingredient

• Main Authors: JEON, RA OK, KIM, EUN HAE, LEE, EUN, AN YING
• Format: Patent
• Language: English; Korean
• Published: 15.03.2018
• Subjects: CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to benzoxazole or a benzothiazole compound, a production method thereof, and a pharmaceutical composition for preventing or treating a cancer containing the same as an active ingredient. According to the present invention, the benzoxazole or the benzothiazole compound with a novel structure represents significantly excellent aurora B kinase inhibitory activity even with low concentration, thereby being used as the pharmaceutical composition for preventing or treating a cancer. 본 발명은 벤조옥사졸 또는 벤조티아졸 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규한 구조의 벤조옥사졸 또는 벤조티아졸 화합물은 낮은 농도에서도 현저히 우수한 오로라 B 키나아제 억제활성을 나타내므로, 이를 암의 예방 또는 치료용 약학적 조성물로서 사용할 수 있는 효과가 있다.