Regioselective synthesis of alkyl EGCG derivatives

The present invention relates to a synthesis method for regioselective alkylation of ((-)-epigallocatechin gallate (-)-EGCG), and in the regioselective alkylation of the (-)-EGCG according to the present invention, EGCG is firstly acetylated and alkylated without directly alkylating EGCG, thereby pr...

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Bibliographic Details
Main Authors SEO, YOU JIN, KIM, MI KYOUNG, CHONG, YOU HOON
Format Patent
LanguageEnglish
Korean
Published 25.01.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a synthesis method for regioselective alkylation of ((-)-epigallocatechin gallate (-)-EGCG), and in the regioselective alkylation of the (-)-EGCG according to the present invention, EGCG is firstly acetylated and alkylated without directly alkylating EGCG, thereby producing 4-alkylated-EGCG with a high yield. 본 발명은 에피갈로카테킨 갈레이트 ((-)-epigallocatechin gallate, (-)-EGCG)의 위치 선택적 알킬화를 위한 합성방법에 관한 것으로, 본 발명에 따른 EGCG의 위치 선택적인 알킬화 방법은, EGCG를 바로 알킬화하지 않고, EGCG를 먼저 아세틸화한 다음 알킬화를 실시함에 따라서, 4''-알킬화-EGCG를 높은 수득률로 제조할 수 있는 효과가 있다.
Bibliography:Application Number: KR20160150006