Composition for prevention improvement or treatment of peripheral neuropathy comprising Stemonae Radix extract as effective component

• Main Authors: KIM, NO SOO, BANG, OK SUN, PARK, JONG SHIK, KIM, YOUNG AH, LEE, YOU JIN, YI, JIN MU, KIM, JIN HEE, LIM, CHAE JUN, CHO, EUN SANG
• Format: Patent
• Language: English; Korean
• Published: 27.12.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a composition for preventing, alleviating or treating peripheral neuropathy, particularly chemotherapy-induced peripheral neuropathy (CIPN), which comprises an extract of Stemonae Radix as an active ingredient. Particularly, according to the present invention, it is shown that an extract of Stemonae Radix alleviates inhibition against growth of neurites caused by an anti-cancer agent and effectively reduces increased sensitivity to stimuli in an animal model of chemotherapy-induced peripheral neuropath while not causing toxicity in normal cells and not affecting the unique cytotoxic effect of an anti-cancer agent in a human cancer cell line. Thus, the extract of Stemonae Radix can be used as an active ingredient of a composition for preventing, alleviating or treating chemotherapy-induced peripheral neuropathy. 본 발명은 백부근(Stemonae Radix) 추출물을 유효성분으로 함유하는 말초신경병증(peripheral neuropathy), 특히 항암제로 유발된 말초신경병증(chemotherapy-induced peripheral neuropathy, CIPN) 예방, 개선 또는 치료용 조성물에 관한 것으로, 구체적으로 본 발명의 백부근 추출물은 정상세포에 독성을 유발하지 않고, 인간 암세포주에서 항암제의 고유한 세포독성 효력에 영향을 주지 않으면서 동시에, 항암제에 의한 신경돌기 성장 억제를 완화하며, 항암제 유발 말초신경병증 동물모델에서 증가된 자극에 대한 민감도를 효과적으로 감소시키는 것을 확인함으로써, 상기 백부근 추출물은 항암제로 유발된 말초신경병증 예방, 개선 또는 치료용 조성물의 유효성분으로 유용하게 사용될 수 있다.