METHOD FOR PREPARING LIPOSOME PREPARATION CONTAINING AMPHOTERICIN B WITH INCREASED ENTRAPMENT EFFICIENCY AND IMPROVED STORAGE STABILITY, AND LIPOSOME PREPARATION OBTAINED THEREFROM

The present invention relates to a method for preparing a liposome preparation containing amphotericin B, and a liposome preparation containing amphotericin B prepared thereby. According to the preparation method of the present invention, provided is a liposome preparation containing amphotericin B,...

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Bibliographic Details
Main Authors PARK, MORK SOON, KIM, JUNG KWON, OH, SANG KWON, JUNG, GOO YOUNG
Format Patent
LanguageEnglish
Korean
Published 19.01.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a method for preparing a liposome preparation containing amphotericin B, and a liposome preparation containing amphotericin B prepared thereby. According to the preparation method of the present invention, provided is a liposome preparation containing amphotericin B, in which free amphotericin B that is not enclosed in the liposome is maintained at a content of less than 1%, and amphotericin B is stably enclosed in the liposome, thereby reducing cytotoxicity to normal cells, increasing enclosing efficiency to improve productivity, and controlling the grain particle distribution to improve storage stability.
Bibliography:Application Number: KR20130101364