PREPARATION METHOD OF SUSTAINED-RELEASE MICROCAPSULES HAVING GOOD INITIAL BURST INHIBITING PROPERTY AND THE MICROCAPSULES THEREBY

• Main Authors: PARK, SEON SOON, JUNG, HYUNG JOON, CHA, KYUNG HOI, PARK, MORK SOON, LIM, NAK HYUN, JUNG, GOO YOUNG, KIM, SE YEON, KIM, JUNG KWOUN
• Format: Patent
• Language: English
• Published: 24.03.2008
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR RELEVANT APPARATUS; TRANSPORTING

A method for preparing a microcapsule is provided to produce a sustained-release medicine having an excellent initial burst-suppressing property, by preparing the microcapsule to contain physiological activation material. A microcapsule is prepared by adding emulsion into an aqueous solution. The emulsion contains physiological activation material, bio-compatible polymer, and polyvinylpyrrolidone. The emulsion is obtained by mixing a first non-aqueous solution containing the physiological activation material and a second non-aqueous solution containing the bio-compatible polymer and the polyvinylpyrrolidone.