PROCESS FOR PREPARING CHIRAL SUBSTITUTED CYCLOPROPANE CARBOXAMIDE

Provided is a method for preparing a chiral substituted cyclopropane carboxamide, which avoids a need for expensive chiral separating agent, such as a chiral amine or L-menthol, or a complicated fermentation step, produces the target product with high optical purity and yield, and is cost-efficient....

Full description

Saved in:
Bibliographic Details
Main Authors YOO, JI SANG, KIM, JI SHICK, SON, JAE MIN, ROH, KYOUNG ROK, JANG, JONG WON
Format Patent
LanguageEnglish
Published 21.11.2006
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:Provided is a method for preparing a chiral substituted cyclopropane carboxamide, which avoids a need for expensive chiral separating agent, such as a chiral amine or L-menthol, or a complicated fermentation step, produces the target product with high optical purity and yield, and is cost-efficient. The method for preparing a chiral substituted cyclopropane carboxamide comprises the steps of: (1) reacting racemic cyclopropane carboxylate represented by the following formula 3 with lipase derived from Candida antarctica in an organic solvent in which ammonia gas is dissolved at a predetermined reaction temperature; and (2) separating (S)-cyclopropane carboxamide compound represented by the following formula 1 from (R)-cyclopropane carboxamide compound represented by the following formula 2.
Bibliography:Application Number: KR20050122129