SUBSTITUTED 1,2,3,4-TETRAHYDROCYCLOPENT(B)INDOLES, 1,2,3,3A,4,8A-HEXAHYDROCYCLOPENT(B)INDOLES AND RELATED COMPOUNDS, INTERMEDIATES AND A PROCESS FOR THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS

• Main Authors: PALERMO, MARK GABRIEL, MERRIMAN, MICHAEL CLAYTON, O'MALLEY, GERARD JOSEPH, ONG, HELEN HU
• Format: Patent
• Language: English; Korean
• Published: 15.11.1999
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

알쯔하이머 질환과 같은 콜린작용 결손에 의해 특징지워지는 다양한 기억 기능장애를 경감시키는데 유용한 다양한 일반식(I)의 화합물이 기술되어 있다. 상기식에서, n, X 및 R내지 R는 명세서에서 정의한 바와 같다. 본 발명의 화합물은 또한 모노아민 옥시다제를 억제하고/하거나 중추 α-아드레날린 작동 수용체에 작용하므로 항억제제로서 유용하다. 본 발명의 화합물은 또한 상기 화합물을 제조하기 위한 There are disclosed various compounds of the formula below, where n, X and R1 through R4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and/or act at central alpha 2-adrenergic receptors, and hence are useful as antidepressants. The invention relates also to intermediates and a process for the preparation of the above compounds.