NITROXYALKYLAMIDE DERIVATIVE

[구성] 하기 일반식 (Ⅰ) 의 니트록시알킬아미드 유도체 : R-(A)-CONH-B-ONO(I) [R: 임의로 치환된 헤테로시클릭, 헤케로시클릭 - 옥시, 아릴옥시 또는 아릴티오기; A : C∼ C알킬렌기; B : C∼ C알킬렌기; n : 0 또는 1 ] [효과] 본 발명의 화합물은 측부 혈관 확장 작용 및 항 - 협심 작용이 뛰어나므로, 협심증의 치료제로서 유용하다. Constitution: a nitroxyalkylamide derivative represented by the general formula (I): R -(A)n...

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Bibliographic Details
Main Authors KOIKE, HIROYUKI, MIYAKE, SHIKEKI, SAITO, FUJIO, KATAOKA, MITSURU, MIZUNO, HIROSHI, ISHIHARA, SADAO
Format Patent
LanguageEnglish
Korean
Published 15.11.1999
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:[구성] 하기 일반식 (Ⅰ) 의 니트록시알킬아미드 유도체 : R-(A)-CONH-B-ONO(I) [R: 임의로 치환된 헤테로시클릭, 헤케로시클릭 - 옥시, 아릴옥시 또는 아릴티오기; A : C∼ C알킬렌기; B : C∼ C알킬렌기; n : 0 또는 1 ] [효과] 본 발명의 화합물은 측부 혈관 확장 작용 및 항 - 협심 작용이 뛰어나므로, 협심증의 치료제로서 유용하다. Constitution: a nitroxyalkylamide derivative represented by the general formula (I): R -(A)n-COHN-B-ONO2, wherein R represents optionally substituted heterocyclic, heterocyclic oxy, aryloxy or arylthio; A represents C1-C4 alkylene; B represents C1-C4 alkylene; and n represents 0 or 1. Effect: this compound is excellent in collateral vasodilatory and antianginal activities and hence is useful as a remedy for angina pectoris.
Bibliography:Application Number: KR19940701515