HEPATITIS C VIRUS EPITOPES

• Main Authors: REYES, GREGORY, MOECKLI, RANDOLF, SIMONSEN, CHRISTIAN, KIM, JUNGSUH P
• Format: Patent
• Language: English; Korean
• Published: 01.09.1999
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

본 발명에서는 C형 간염 바이러스(HCV)로 감염된 개체로 부터의 혈청과 면역반응하는 펩티드 항원이 개시된다. 여러 항원은 만성 및 급성 HCV 감염을 가지는 것으로 확인된 개체에 존재하는 항체와 면역학적으로 반응한다. 항원은 사람에서 HCV 감염 검출을 위한 진단 방법에 유용하다. 또한 본 발명에는 항원성 펩티드에 대한 오픈 리딩 프레임 서열을 코드화하는 폴리누클레오티드를 함유하는 해당 게놈성 단편 클론들이 개시된다. Peptide antigens which are immunoreactive with sera from individuals infected with hepatitis C virus (HCV) are disclosed. Several of the antigens are immunologically reactive with antibodies present in individuals identified as having chronic and acute HCV infection. The antigens are useful in diagnostic methods for detecting HCV infection in humans. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic peptides.