CRYSTALLINE ACID ADDITIION SALTS OF DIASTEREOMERICALLY PURE 1-(2,2-DIMETHYLPROPIONYLOXY)-ETHYL-3-CEPHEM-4-CARBOXYLATE, PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF

• Main Authors: JOACHIM-HEINER, JENDRALLA, GERD, FISCHER, THEODOR, WOLLMANN, RUDOLF, LATTRELL, DIETER, ISERT, ELISABETH, DEFOBA
• Format: Patent
• Language: English; Korean
• Published: 15.06.1999
• Edition: 6
• Subjects: APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 하기 일반식(II)의 1-(2,2-디메틸프로피오닐옥시)에틸 3-세펨-4-카복실레이트의 2개의 부분입체이성질체의 결정성 산부가염, 세균 감염에 대한 활성이 있으며 이러한 세펨 유도체를 함유하는 약제학적 제제, 세펨 유도체의 제조방법 및 세균 감염에 대항하기 위한 세펨 유도체의 용도에 관한 것이다. 상기식에서, x 는 생리학적으로 허용되는 일- 또는 다염기, 무기 또는 유기산의 음이온이며, 그룹 =N-OH 은 신-위치에 존재한다. The invention relates to crystalline acid addition salts of the two diastereomers of the 1-(2,2-dimethylpropionyloxy)ethyl ester of 3-cephem-4-carboxylic acid of the general formula II in which X represents the anion of a physiologically acceptable, mono- or polybasic, inorganic or organic acid and the group =N-OH is in the syn position, pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, a process for the preparation of the cephem derivatives, and the use of the cephem derivatives for the control of bacterial infections.