HYDROXYMETHYL-INDOLIZIDINES AND QUINOLIZIDINES

• Main Authors: RHINEHART, BARRY L, KANG, MOHINDER S, ROGERS, ROLAND S, LIU, PAUL S
• Format: Patent
• Language: English; Korean
• Published: 15.06.1999
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 폴리히드록실화 인돌리지딘 및 퀴놀리지딘, 및 그의 에스테르에 관한 것이다. 본 발명 화합물은 2,6-디데옥시-2,6-아미노-1,3,4,5-테트라키스-O-(페닐메틸)-D-글리세로-L-글로 헵티톨 또는 대응하는 N-치환 화합물을 출발 물질로 하여 제조한다. 본 발명 화합물은 당뇨병 치료 및 α-글루코시다아제 I 억제제로서 유용하다. The present invention describes a group of polyhydroxylated indolizidines and quinolizidines and their esters. These compounds are prepared starting from 2,6-dideoxy-2,6-imino-1,3,4,5-tetrakis-O-(phenylmethyl)-D-glycero-L-gu lo-heptitol or a corresponding N-substituted compound. The compounds are useful in the treatment of diabetes and as alpha -glucosidase I inhibitors.