TARGET SPECIFIC ANTIBODY-SUPERANTIGEN CONJUGATES AND THEIR PREPARATION

• Main Authors: KALLAND, TERJE, HEDLUND, GUNNAR, LANDO, PETER, DOHLSTEN, MIKAEL, AKERBLOM, EVA
• Format: Patent
• Language: English; Korean
• Published: 01.06.1999
• Edition: 6
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 항체 및 초항원을 포함하는 가용성 항체 접합체 및 그의 제조방법에 관한 것이다. 또한 본 발명은 T세포에 의해 인지 가능한 구조인 초항원과 결합하는 항체를 포함하는 가용성 항체 접합체의 표적 세포 용해 유효량과 관련된 표적 세포의 세포 용해 방법에 관한 것이다. 또한 상기 접합체를 포함하는 제약학적 조성물 및 그의 제조 방법을 포함하는 신규한 가용성 항체 접합체에 관한 것이다. A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regimen for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections. The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.