MONOCLONAL ANTIBODY RECOGNIZING MEMBRANE PHOSPHOLIPASE A2 AND IMMUNOASSAY OF MEMBRANE PHOSPHOLIPASE A2

• Main Authors: KANDA, AKIKO, KONO, MASAO, IDE, MISAO, YOSHIDA, NOBUO
• Format: Patent
• Language: English; Korean
• Published: 01.06.1999
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

본 발명은 먼저 막형 포스포리파제 A를 인식하는 모노크로날 항체 즉, 모노크로날 항체 PL-49, PL-71, PL-76 및 PL-78, 이들을 생산하는 하이브리도마, 이들을 생산하는 방법 및 이들을 사용한 막형 포스포리파제 A의 면역 측정법을 제공한다. PLAM의 면역 측정법은 관절 류마티즘, 암 및 각종 염증 상태의 진단에 유용하다. The present invention first provides monoclonal antibodies recognizing membrane phospholipase A2, namely, monoclonal antibodies PL-49, PL-71, PL-76, and PL-78, hybridomas producing them, methods for producing them, and immunoassays of membrane phospholipase A2 using them. The immunoassay of PLA2M is useful for the diagnosis of articular rheumatism, cancers, and a wide variety of inflammatory states.