11-KETO OR HYDROXY 3,5-DIENE STEROIDS AS INHIBITORS OF STEROID 5-ALPHA-REDUCTASE AND PHARMACEUTICAL COMPOSITION

• Main Authors: LEVY, MARK ALAN, HOLT, DENNIS ALAN, METCALF, BRIAN WALTER
• Format: Patent
• Language: English; Korean
• Published: 01.06.1999
• Edition: 6
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

합성 스테로이드 화합물의 카복실 및 카복실알킬에스테르 치환된 11-케토 및 하이드록시 유사체, 이들 화합물을 함유하는 약제학적 조성물 및 이들 화합물을 사용하여 스테로이드 5α-리덕타제를 억제하는 방법이 발명되었다. Compounds of structure: in which X is keto or H and OH; R is H or C1-8alkyl; R is (1) alpha -H, alpha =OH or alpha -acetoxy and/or beta -WCOR where W is a bond or C1-12alkyl and R is C1-8alkyl, C1-8alkoxy of N(R )2 where R is, inter alia, H or C1-8alkyl; (2) =CHWCOR or =CHWOR where W and R are as above and R is, inter alia, phenylalkylcarbonyl, benzoyl, alkoxycarbonyl, aminocarbonyl, alkyl or alkylcarbonyl; (3) alpha -H and beta -NHCOR where R is alkyl or beta -N(R )2 or (4) keto, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of 5- alpha -reductase.