PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS

• Main Authors: DICKERSON, SCOTT HOWARD, JOHNSON, JULIUS VASS, FERONE, ROBERT
• Format: Patent
• Language: English; Korean
• Published: 01.05.1999
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

내용 없음. Compounds of formula (I) or salts thereof, wherein the dotted line represents a single or double bond, R is alkyl or amino optionally substituted by alkyl, alkanoyl or benzyl group; R , R , R and R are the same or different and each is selected from hydrogen, phenyl, halo, nitro, a group S(O)nR wherein n is the integer 0, 1 or 2 and R is halo or alkyl or a group NR R wherein R and R are both hydrogen, a group NR R wherein R and R are the same or different and each is hydrogen or alkyl, a group OR wherein R is hydrogen or C1-4 alkyl optionally substituted by halo; a C1-4 aliphatic group optionally substituted by a group OR or NR R wherein R and R are the same or different and each is hydrogen or alkyl; or two of R to R are linked together to form a benzo group, or one of R to R is a group -X-Y-R wherein X is CH2, NR , CO or S(O)m, and Y is CH2, NR , O, or S(O)m, or -X-Y- is a group -O-, -NR -, -CH=CH- or -N=N-, are disclosed as pharmacological agents useful in the treatment of tumours. Pharmaceutical compositions and methods for the preparation of compounds of formula (I) are also described.