ENANTIOSELECTIVE OXAZABOROLIDINE CATALYSTS

• Main Author: QUALLICH, GEORGE J
• Format: Patent
• Language: English; Korean
• Published: 15.05.1999
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

광학적으로 순수한 알콜로의 프로키랄 케톤의 거울상선택적 보란 환원은 일반식(I) 및 (II)의 신규하고도 유용한 촉매량의 옥사자보로리딘 화합물의 존재하에 환원을 수행함으로써 유효하게 성취된다. 일반식(I) 및 (II)의 화합물은 환원 반응에 사용하기 이전에 분리 및 정제될 수있거나 일반식(I) 및 (II)의 화합물은 동일 반응계에서 생성될 수 있다. The anantoselective borane reduction of prochiral ketones to optically pure alcohols is effectively achieved by performing the reduction in the precence of catalytic amounts of the new and valuable oxazaborolidine compounds of formulas (I) and (II). The compounds of formulas (I) and (II) may be isolated and purified prior to use in the reduction reactions or the compounds of formulas (I) and (II) may be generated in situ.