MILBEMYCIN ETHER DERIVATIVES, THEIR PREPARATION AND THEIR ANTHELMIN

• Main Authors: KAN OLLEYRES. LOUIS-PIERRE, GEHRET, JEAN-CLAUDE, MORISAWA, YASUHIRO
• Format: Patent
• Language: English; Korean
• Published: 01.12.1998
• Edition: 6
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; DERIVATIVES THEREOF; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS; TRAPPING

하기 일반식(I)의 화합물 및 그의 염과 에스테르는 유용한 구충, 살비 및 살충 활성을 갖는다. 상기 일반식에서, R은 수소, 할로겐, 시아노, 니트로, 임의 치환된 알킬, 알콕시, 알콕시알콕시 또는 하기 일반식들의 기 : (식중, m은 1 또는 2 이고, n은 0, 1 또는 2 이며, R는 수소 또는 각종 유기성 기이고 ; R는 알킬, 시클로알킬 또는 아르알킬이며 ; R는 수소 또는 알킬이고 ; R은 R중 임의의것, 또는 시아노, 니트로-COOR또는 -COR이며 ; Y 는 산소 또는 황이고 Z는 -COOR, -COR또는 -SOS이다) 의 기이고; A는 하기 일반식 : (식중, R, R및 R는 수소이고, 할로겐, 알킬 또는 알콕시이다)의 기이다. 본 화합물의 제조방법도 제공된다. A process of formula (I): [in which: R is hydrogen, halogen, cyano, nitro, optionally substituted alkyl, alkoxy, alkoxyalkoxy, or a group of formula: in which: m is 1 or 2; n is 0, 1 or 2; R is hydrogen or a variety of organic groups; R is alkyl, cycloalkyl, or aralkyl; R is hydrogen or alkyl; R is any of R , or cyano, nitro, -COOR or -COR ; Y is an oxygen or a sulphur; Z is -COOR , -COR or -SO2R ; A is a group of formula: -CHR -CHR -CHR - -CR =CR -CHR - or in which R , R and R are hydrogen, halogen, alkyl or alkoxy; R is methyl, ethyl, isopropyl or sec-butyl; and X is hydroxy, optionally substituted alkanoyloxy or hydroxyimino] and salts and esters thereof have valuable anthelmintic, acaricidal and insecticidal activities. Methods of preparing the compounds are also provided.