ACYLATION PROCESS

7 beta -[2-(2-Tritylaminothiazol-4-yl )-2-(t-butyloxycarbonylprop-2-yl )oxyiminoacetamido]-3-pyridiniummethyl-3-cephem-4-carboxylate 1 is obtained via a process comprising N-acylation of 7 beta -amino-3-pyridiniummethyl-3 -cephem-4-carboxylate 1A with a mixed anhydride of 2-(2-tritylaminothiazol-4-y...

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Bibliographic Details
Main Authors WIRTH, DAVID DALE, MCSHANE, LAWRENCE JOSEPH
Format Patent
LanguageEnglish
Korean
Published 01.12.1998
Edition6
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:7 beta -[2-(2-Tritylaminothiazol-4-yl )-2-(t-butyloxycarbonylprop-2-yl )oxyiminoacetamido]-3-pyridiniummethyl-3-cephem-4-carboxylate 1 is obtained via a process comprising N-acylation of 7 beta -amino-3-pyridiniummethyl-3 -cephem-4-carboxylate 1A with a mixed anhydride of 2-(2-tritylaminothiazol-4-yl)-2-(t-butyloxycarbonylprop-2-yl)oxyiminoa cetic acid formed with a sulfonic acid halide or phosphoric acid halide, preferably carried out with silylated 1A. The process provides substantial yields of 1 of high purity.
Bibliography:Application Number: KR19890019012