FUMAGILLOL DERIVATIVES

The present invention is related to a compound of the formula wherein R is a 2-methyl-1-propenyl or isobutyl group which may be substituted and R is (1) a substituted alkanoyl group, (2) a substituted aroyl group having at least one substituent selected from the group consisting of C2-6 alkyl, amino...

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Bibliographic Details
Main Authors KISHIMOTO, SHOJI, FUJITA, TAKESHI
Format Patent
LanguageEnglish
Korean
Published 15.05.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention is related to a compound of the formula wherein R is a 2-methyl-1-propenyl or isobutyl group which may be substituted and R is (1) a substituted alkanoyl group, (2) a substituted aroyl group having at least one substituent selected from the group consisting of C2-6 alkyl, amino, halogen, hydroxyl, lower alkoxy, cyano, carbamoyl and carboxyl, (3) an aromatic heterocycle-carbonyl, which may optionally be substituted, (4) a carbamoyl group, which may optionally be substituted, (5) an alkyl group, which may optionally be substituted, (6) a benzenesulfonyl group, which may optionally be substituted, (7) an alkylsulfonyl group, which may optionally be substituted, (8) a sulfamoyl group, which may optionally be substituted, (9) an alkoxycarbonyl group, which may optionally be substituted or (10) a phenoxycarbonyl group, which may optionally be substituted; or a salt thereof. The compound (I) has a strong angiogenesis inhibitory activity.
Bibliography:Application Number: KR19890012548