配位子及びＣＥＡＣＡＭ５抗体Ｆａｂフラグメントからなる複合体

• Format: Patent
• Language: Japanese
• Published: 11.11.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

【課題】 金属や蛍光色素等による標識によっても結合活性が減弱しない抗ヒトＣＥＡＣＡＭ５抗体Ｆａｂフラグメントを用いた、体内診断薬および放射線内用療法に有用な配位子、スペーサー、及びペプチドリンカーからなる複合体の提供。【解決手段】 特定のアミノ酸配列からなる重鎖可変領域を含む重鎖フラグメント及び特定のアミノ酸配列からなる軽鎖可変領域を含む軽鎖を含む、抗ヒトＣＥＡＣＡＭ５抗体Ｆａｂフラグメント及び配位子を含む複合体又は配位子、スペーサー、及びペプチドリンカーからなる複合体は、金属や蛍光色素等による標識によっても結合活性が減弱せず、診断用組成物及び／又は医薬組成物として使用できる。【選択図】 なし Provided is a conjugate comprising a ligand, a spacer, and a peptide linker useful for an in-vivo diagnostic drug and internal radiation therapy, using an anti-human CEACAM5 antibody Fab fragment whose binding activity is not attenuated even by labeling with a metal, a fluorescent dye, or the like. A conjugate comprising an anti-human CEACAM5 antibody Fab fragment and a ligand, the fragment comprising a heavy chain fragment including a heavy chain variable region consisting of a specific amino acid sequence and a light chain including a light chain variable region consisting of a specific amino acid sequence, or a conjugate comprising a ligand, a spacer, and a peptide linker, wherein the binding activity thereof is not attenuated even by labeling with a metal, a fluorescent dye, or the like, can be used as a diagnostic composition and/or a pharmaceutical composition.