CYCLIC AMINE DERIVATIVE

NEW MATERIAL:The compound of formula I [J is phenylpyridyl, pyrazyl, indanyl, indanonyl, univalent group derived from cyclic amide or alkyl; B is group of formula II-IV (n is 0-10; R is H or methyl; R is H, alkyl, acylphenyl, etc.; R is H, alkyl or phenyl), etc.; T is N or C; Q is T or N O; K is H,...

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Main Authors HIGURE KUNIZO, KARIBE NORIO, KUBOTA ATSUHIKO, OZASA MICHIKO, SUGIMOTO HACHIRO, YAMANISHI YOSHIHARU, OZASA TAKASHI, YAMATSU KIYOMI, OGURA HIROO, SASAKI ATSUSHI, ARAKI SHIN, TSUCHIYA YUTAKA, IIMURA YOICHI
Format Patent
LanguageEnglish
Published 24.03.1989
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:The compound of formula I [J is phenylpyridyl, pyrazyl, indanyl, indanonyl, univalent group derived from cyclic amide or alkyl; B is group of formula II-IV (n is 0-10; R is H or methyl; R is H, alkyl, acylphenyl, etc.; R is H, alkyl or phenyl), etc.; T is N or C; Q is T or N O; K is H, phenyl, arylalkyl, alkyl, pyridylmethyl, etc.; q is 1-3] and its salt. EXAMPLE:1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl) methylpiperidine. USE:It has strong and highly selective anti-acetylcholine esterase activity and is useful as a preventive and remedy for senile dementia. PREPARATION:A compound of formula I wherein B is group of formula IV can be produced e.g., by reacting an acid halide of formula V (Hal is halogen) with a cyclic amine derivative of formula VI in the presence of a salt-removing agent.
Bibliography:Application Number: JP19880153852