2,2'-BIS(DI-(P-METHOXYPHENYL)PHOSPHINO)-1,1'-BINAPHTHYL

• Main Authors: SAYO NOBORU, TAKATANI HIDEMASA, NAGAI KATSUNORI, KUMOBAYASHI HIDENORI, AKUTAGAWA SUSUMU, OTA TETSUO, TAKETOMI TAKANAO, NOYORI RYOJI, KITAMURA MASAHITO
• Format: Patent
• Language: English
• Published: 14.03.1989
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

NEW MATERIAL:A compound expressed by formula I. USE:A ligand of a catalyst for asymmetric synthesis, forming an extremely important complex as an asymmetric synthetic catalyst together with a metallic element such as rhodium, and remarkably enhancing the conversion rate in asymmetric synthesis. PREPARATION:Phosphorus oxychloride is initially reacted with diethylamine in benzene while cooling with an ice to form N,N-diethylamidedichlorophosphate expressed by formula II. Then the compound is reacted with a Grignard reagent expressed by formula III, which is obtained from p-bromoanisole, in THF (tetrahydrofuran), and the resultant product is reacted with thionyl chloride to afford di-(p-methoxyphenyl)phosphonylchloride expressed by formula IV. Subsequently, the compound is reacted with a Grignard reagent expressed by formula V, which is obtained by treating 2,2-dibromo-1,1-binaphthyl with Mg, to afford a compound expressed by formula VI, which is successively subjected to optical resolution and reduction.