LEUKOTRIENE ANTAGONIST

The invention provides disubstituted tetrazoles that antagonize the effect of leukotrienes C4, D4 or E4 or any combination thereof in selected tissues, which are of the formula wherein: R1 is C1 to C8 alkyl or phenyl; R2 is C2 to C8 alkyl or C3 to C6 alkenyl; L1 is C3 to C10 alkylidene or phenyl; [T...

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Bibliographic Details
Main Authors UINSUTON SUTANREI MAASHIYARU, SANDORA KEI SHIGUMANDO, SERIA AN HOWAITOJITSUTO
Format Patent
LanguageEnglish
Published 13.03.1989
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides disubstituted tetrazoles that antagonize the effect of leukotrienes C4, D4 or E4 or any combination thereof in selected tissues, which are of the formula wherein: R1 is C1 to C8 alkyl or phenyl; R2 is C2 to C8 alkyl or C3 to C6 alkenyl; L1 is C3 to C10 alkylidene or phenyl; [Tet] is a disubstituted 1H- or 2H-tetrazolyl ring, of the formula: L2 is 1) a C1 to C10 alkylidene group; or 2) a benzyl group of the formula: wherein R7 is a hydrogen atom, hydroxy group, or acetoxy; and n is from 0 to 3; (and the single methylene group bonded to the ring is also bonded to the tetrazolyl ring [Tet]); A is 1) a group of the formula -COOH; or 2) a 5-(tetrazolyl) group; with the proviso that when L1 is phenyl, -L2-A cannot be bonded to the five position of [Tet] tetrazolyl ring; or a pharmaceutically-acceptable salt thereof.
Bibliography:Application Number: JP19880202627