LEUKOTRIENE ANTAGONIST
The invention provides disubstituted tetrazoles that antagonize the effect of leukotrienes C4, D4 or E4 or any combination thereof in selected tissues, which are of the formula wherein: R1 is C1 to C8 alkyl or phenyl; R2 is C2 to C8 alkyl or C3 to C6 alkenyl; L1 is C3 to C10 alkylidene or phenyl; [T...
Saved in:
Main Authors | , , |
---|---|
Format | Patent |
Language | English |
Published |
13.03.1989
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The invention provides disubstituted tetrazoles that antagonize the effect of leukotrienes C4, D4 or E4 or any combination thereof in selected tissues, which are of the formula wherein: R1 is C1 to C8 alkyl or phenyl; R2 is C2 to C8 alkyl or C3 to C6 alkenyl; L1 is C3 to C10 alkylidene or phenyl; [Tet] is a disubstituted 1H- or 2H-tetrazolyl ring, of the formula: L2 is 1) a C1 to C10 alkylidene group; or 2) a benzyl group of the formula: wherein R7 is a hydrogen atom, hydroxy group, or acetoxy; and n is from 0 to 3; (and the single methylene group bonded to the ring is also bonded to the tetrazolyl ring [Tet]); A is 1) a group of the formula -COOH; or 2) a 5-(tetrazolyl) group; with the proviso that when L1 is phenyl, -L2-A cannot be bonded to the five position of [Tet] tetrazolyl ring; or a pharmaceutically-acceptable salt thereof. |
---|---|
Bibliography: | Application Number: JP19880202627 |