GLYCERIN DERIVATIVE

NEW MATERIAL:A compound expressed by formula I [R is (substituted)higher alkyl; R is H, (substituted)lower alkyl, (substituted)lower alkanoyl, etc.; R is primary - tertiary amino or quaternary ammonium; n is 2 or 3] or salt thereof. EXAMPLE:1-0-Octadecyl-3-0-[2-(2-trityloxyethoxy)ethyl] glycerin. US...

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Bibliographic Details
Main Authors INOUE KEIZO, OKUYA TETSUYA, NOMURA MASAAKI
Format Patent
LanguageEnglish
Published 10.01.1989
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:A compound expressed by formula I [R is (substituted)higher alkyl; R is H, (substituted)lower alkyl, (substituted)lower alkanoyl, etc.; R is primary - tertiary amino or quaternary ammonium; n is 2 or 3] or salt thereof. EXAMPLE:1-0-Octadecyl-3-0-[2-(2-trityloxyethoxy)ethyl] glycerin. USE:An antiulcer agent and plalet-activating factor antagonist. Useful also in prevention and remedy for circulation hindrance disease and allergy because of having plalet-activating factor antagonism. PREPARATION:A compound expressed by formula XI is reacted with a sulfonic acid halide in a proper deacidifying agent (e.g. triethylamine) at -20-100 deg.C, preferably -10-50 deg.C to afford formula XI' (R is benzenesulfonyl), which is reacted with an amine to provide the compound expressed by formula I wherein R is (substituted)lower alkyl.
Bibliography:Application Number: JP19870176512