PRODUCTION OF PROSTAGLANDIN E1 DERIVATIVE

• Main Authors: SUGIURA SATOSHI, TANAKA TOSHIO, KUROZUMI SEIJI
• Format: Patent
• Language: English
• Published: 09.04.1988
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL METHODS OF ORGANIC CHEMISTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE; THEIR RELEVANT APPARATUS; TRANSPORTING

PURPOSE:To industrially advantageously produce the titled compound useful as a medicine, by reducing a double bond in 7 and 8 position of DELTA -prostaglandin E1 derivative with a metal-hydrogen complex compound and organotin halide. CONSTITUTION:A DELTA -prostaglandin E1 derivative expressed by formula I (R is H, alkyl, phenyl, cycloalkyl or phenylalkyl; R and R are protecting group of H or OH; R is H, methyl, ethyl, ethynyl or vinyl; R is hydrocarbon, phenyl, phenoxy, cycloalkyl, phenyl, etc.; A is methylene or O;B is single bond or methylene) is reduced with a metal-hydrogen complex compound (e.g. sodium borohydride, etc.) and organotin halide (e.g. tributyltin chloride, etc.) to provide a prostagrandin E1 derivative expressed by formula II. In above-mentioned production, a catalyst system readily available can be used and the aimed product can be produced in high yield.