NOVEL POLYSACCHARIDES

PURPOSE:To obtain novel polysaccharides which comprises a low-molecular beta-1,3-glucan excellent in water solubility and can give an antitumoral agent which shows an excellent effect at a low dosage, by extracting volvaria with an aqueous alkali solution and decreasing the MW of the extract. CONSTI...

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Bibliographic Details
Main Authors KOIWA SHIGEJI, SAWADA YUJI, NISHI AKIHIRO, MISAKI AKIRA
Format Patent
LanguageEnglish
Published 08.04.1988
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
THEIR PREPARATION OR CHEMICAL WORKING-UP
VINEGAR
WINE
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Summary:PURPOSE:To obtain novel polysaccharides which comprises a low-molecular beta-1,3-glucan excellent in water solubility and can give an antitumoral agent which shows an excellent effect at a low dosage, by extracting volvaria with an aqueous alkali solution and decreasing the MW of the extract. CONSTITUTION:Fruit bodies or mycelia of volvaria are extracted with 5-100pts.wt., per pt.wt. their dry weight per extraction, an aqueous alkali solution (0.1-3-N concentration) at 30 deg.C or below in an inert gas atmosphere such as nitrogen, and quaternary acidic substances, etc., are precipitated from the extract by the addition of a quat. ammonium salt and filtered off. The supernatant liquid is irradiated with ultrasonic waves at a power of 100-1,000W and a frequency of 5-100kHz for 20-500hr, and this treatment is stopped when the molecular weight reaches several thousand to 100,000 when it is traced by means of gel filtration high-performance liquid chromatography in which dimethyl sulfoxide is used as the mobile phase. A polysaccharide comprising first repeating units of formula I, second repeating units of formula II and third repeating units of formula III (wherein Glu is a glucopyranosyl group and numerals are positions of bonding), wherein the number of said third repeating units present is 4-12 on the average, and the sum of said second and third repeating units is 16-33 is obtained.
Bibliography:Application Number: JP19860222051