NOVEL CARCINOSTATIC ANTIBIOTIC DEOXYCORIOLIC ACID AND PRODUCTION THEREOF

• Main Authors: TAKEUCHI TOMIO, OBAYASHI AKIRA, UMEZAWA HAMAO, OSANAWA HIROSHI, SHIOMI KAZURO, IINUMA HIRONOBU
• Format: Patent
• Language: English
• Published: 22.03.1988
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

NEW MATERIAL:Deoxycoriolic acid shown by the formula. USE:Useful as a carcinostatic agent, especially effective against mouse Ehrlich ascites carcinoma, having low toxicity. PREPARATION:A microorganism belonging to the genus Coriolus, capable of producing deoxycoriolic acid, is cultivated and the compound shown by the formula is obtained. One example of the microorganism, capable of producing deoxycoriolic acid is strain Coriolus consors PS43a which is Basidiomycetes collected at a forest on a mountain at Ohtsu City in Shiga Prefecture, the strain is inoculated into a medium containing a nutritive source and aerobically grown. Mass production of deoxycoriolic acid is preferably carried out by liquid culture and the culture temperature is usually 15-35 deg.C, preferably 27-32 deg.C. After the cultivation, deoxycoriolic acid is extracted with a water non-compatible organic solvent such as butyl acetate, etc., from a culture filtrate at pH <=9 and collected.