SYNTHESIS OF ADENINE NUCLEOSIDE DERIVATIVE

PURPOSE:To obtain a 3'-deoxy-2'-ketoadenosine derivative useful as various intermediates in an extremely high yield, by treating a specific adenosine derivative with a metal alkoxide. CONSTITUTION:A compound expressed by formula I (R and R are trityl or dimethoxytrityl; R is methanesulfony...

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Bibliographic Details
Main Authors KAWANA MASAJIRO, KUZUHARA HIROMI
Format Patent
LanguageEnglish
Published 07.06.1988
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:PURPOSE:To obtain a 3'-deoxy-2'-ketoadenosine derivative useful as various intermediates in an extremely high yield, by treating a specific adenosine derivative with a metal alkoxide. CONSTITUTION:A compound expressed by formula I (R and R are trityl or dimethoxytrityl; R is methanesulfonyl or toluenesulfonyl) is reacted with a metal alkoxide, e.g. magnesium methoxide, sodium lower alkoxide, in an amount of preferably 1-20mol equivalents, preferably at -70-+100 deg.C for 5min-12hr to afford the aimed compound expressed by formula II.
Bibliography:Application Number: JP19860281197