PRODUCTION OF OPTICALLY ACTIVE CIS-IMIDAZOLIDINEDICARBOXYLIC ACID DERIVATIVE

PURPOSE:To produce an optically active cis-imidazolidinedicarboxylic acid derivative useful as an intermediate for synthesizing biotin, etc., efficiently, by using an esterase producing bacterium belonging to the genus Bacillus or esterase derived from the bacterium. CONSTITUTION:An esternase produc...

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Bibliographic Details
Main Authors KUMAGAI KAZUO, YASUKUI HIDEO, FUKITA YOSHIKAZU, TAYA KIYOSHI
Format Patent
LanguageEnglish
Published 20.10.1987
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:PURPOSE:To produce an optically active cis-imidazolidinedicarboxylic acid derivative useful as an intermediate for synthesizing biotin, etc., efficiently, by using an esterase producing bacterium belonging to the genus Bacillus or esterase derived from the bacterium. CONSTITUTION:An esternase producing bacterium such as Bacillus sp. VA-47 strain (FERM P-8730) belonging to the genus Bacillus including alkali-philic Bacillus or esterase derived from the esterase producing bacteria is brought into contact with a cis-imidazolidinedicarboxylic acid diester shown by formula II (R is lower alkyl group; Bzl is benzyl group) to give an optically active cis-imidazolidinedicarboxylic acid derivative shown by formula I (R and Bzl are as shown above).
Bibliography:Application Number: JP19860084482