NOVEL CEPHALOSPORIN COMPOUND AND SALT THEREOF

NEW MATERIAL:The compound formula I [R is H, amino-protecting group or acyl; R is condensed heterocyclic group of formula II (R is H or lower alkyl; ring A is a heterocyclic group sharing N and C with imidazole ring and optionally containing N, O or S); R is H or carboxyl-protecting group]. EXAMPLE:...

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Main Authors YOSHIDA CHOSAKU, TANAKA KIYOSHI, WATANABE YASUO, KOMATSU MIWAKO, KISHIMOTO SUMIKO, TAI MASARU, SAIKAWA ISAMU, SANTO TETSUO
Format Patent
LanguageEnglish
Published 08.08.1987
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:The compound formula I [R is H, amino-protecting group or acyl; R is condensed heterocyclic group of formula II (R is H or lower alkyl; ring A is a heterocyclic group sharing N and C with imidazole ring and optionally containing N, O or S); R is H or carboxyl-protecting group]. EXAMPLE:3-(Imidazo[ 1, 2-a ]pyridin-2-yl)-7-phenylacetamido-DELTA -cephem-4-carboxy lic acid diphenylmethyl ester. USE:An antibacterial agent having excellent antibacterial activity even against strain resistant to penicillin or cephalosporin. It has low toxicity. PREPARATION:The compound of formula VI which is one of the objective compound can be produced e.g. by (1) halogenating the compound of formula III or its sat with a halogenation agent in a solvent preferably at 10-60 deg.C and (2) reacting 1mol of the resultant compound of formula IV with preferably 1-2mol of the compound of formula V in a solvent usually at 0-150 deg.C.
Bibliography:Application Number: JP19860022146