N-CONTAINING CONDENSED HETEROCYCLIC COMPOUND, PRODUCTION THEREOF AND DRUG COMPOSITION CONTAINING SAME

NEW MATERIAL:A compound shown by formula I [R and R are H, halogen, aryl, alkyl, etc.,; R -R are alkylene; X is CH or N; Y is S, O, NH, etc.; Z is O or NH; A is H, nitroso, amidino, NR R (R and R are H, alkyl, acyl, etc.) or N=R (R is alkylidene which may be replaced with arbitrarily substituted ary...

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Bibliographic Details
Main Authors TSUJI KIRYO, UEDA IKUO, MATSUO MASAAKI, NAKAGUCHI OSAMU, OKUMURA HIROYUKI
Format Patent
LanguageEnglish
Published 08.08.1987
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:A compound shown by formula I [R and R are H, halogen, aryl, alkyl, etc.,; R -R are alkylene; X is CH or N; Y is S, O, NH, etc.; Z is O or NH; A is H, nitroso, amidino, NR R (R and R are H, alkyl, acyl, etc.) or N=R (R is alkylidene which may be replaced with arbitrarily substituted aryl)] and a salt thereof. EXAMPLE:5-Chloro-3-[(4-amino-1-piperazinyl)carbonylmethyl]-2-benzothia zolinone. USE:Useful for remedying thrombosis, inflammations, allergic diseases and pains. PREPARATION:For example, a compound shown by formula II or a reactive derivative at its carboxyl group is reacted with a compound shown by formula III or a reactive derivative at its amino group in the presence of condensation agent to give a compound shown by formula I.
Bibliography:Application Number: JP19870008379