NOVEL THEOPHYLLINE DERIVATIVE

NEW MATERIAL:A compound shown by formula I (R is H, lower alkyl or lower alkoxymethyl; n is 1-3; when A is S or sulfinyl, B is 3-alkyl-2- cyanoguanidyl or pyridyl and when A is O or amino, B is pyridyl). EXAMPLE:7-Methyl-3-[2-(3-methyl-2-cyano-1-guadinyl)ethylthio]theophyll ine. USE:An antiulcer hav...

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Bibliographic Details
Main Author HORI MIKIO
Format Patent
LanguageEnglish
Published 01.08.1987
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:A compound shown by formula I (R is H, lower alkyl or lower alkoxymethyl; n is 1-3; when A is S or sulfinyl, B is 3-alkyl-2- cyanoguanidyl or pyridyl and when A is O or amino, B is pyridyl). EXAMPLE:7-Methyl-3-[2-(3-methyl-2-cyano-1-guadinyl)ethylthio]theophyll ine. USE:An antiulcer having well balanced both activities of prevention of attacking factor and protecting action on gastric mucosa and low toxicity. PREPARATION:For example, a compound shown by formula II (R is lower alkyl or lower alkoxymethyl) is reacted with a compound shown by formula III (X is halogen) in a solvent such as DMF, etc., in the presence of an alkali metal hydride at 0-100 deg.C. Then the formed compound shown by formula IV is reacted with an alkylamine at room temperature-100 deg.C to give a compound shown by formula V (B1 is 3-alkyl-2-cyanoguanidyl).
Bibliography:Application Number: JP19860015403