PRODUCTION OF ALPHA-DIHYDROPOLYPRENYL DICHLOROPHOSPHATE

PURPOSE:To obtain the titled compound useful as a rate determining factor for synthesis of glycoprotein, ameliorant of hepatic function, anti-inflammatory agent, immunological enhancer, etc., in high yield, by reacting alpha- dihydropolyprenol with phosphorus oxychloride in an ether based solvent in...

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Bibliographic Details
Main Authors KAGEYU AKIRA, SHIMAMURA MICHIYA, TAKIGAWA TETSUO, MIZUNO MASAO, NAKAGAWA SUNAO, OKADA MASAFUMI
Format Patent
LanguageEnglish
Published 10.07.1987
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PURPOSE:To obtain the titled compound useful as a rate determining factor for synthesis of glycoprotein, ameliorant of hepatic function, anti-inflammatory agent, immunological enhancer, etc., in high yield, by reacting alpha- dihydropolyprenol with phosphorus oxychloride in an ether based solvent in the presence of a basic compound. CONSTITUTION:alpha-Dihydropolyprenol expressed by formula I (m is 4-22) is reacted with preferably 2-10mol equivalents, based on the compound expressed by formula I, phosphorus oxychloride in the presence of preferably 1.5-5mol equivalents, based on the compound expressed by formula I, basic compound, preferably triethylamine or pyridine in an ether based solvent, preferably THF, 1,2-dimethoxyethane or diethyl ether to afford the aimed compound expressed by formula II.
Bibliography:Application Number: JP19850297941