AQUEOUS SOLUTION AGENT

PURPOSE:An aqueous solution agent containing a drug having powerful antiallergic action, etc., and a dissolution adjuvant consisting of polyvinyl pyrrolidone, cyclodextrin and caffeine. CONSTITUTION:An aqueous solution agent obtained by adding 0.05-2wt/vol% compound expressed by the formula (R is 1-...

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Bibliographic Details
Main Authors TERAYAMA HIDEO, SHIMIZU HISAYOSHI, OOSHIMA MITSUAKI
Format Patent
LanguageEnglish
Published 04.06.1987
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE:An aqueous solution agent containing a drug having powerful antiallergic action, etc., and a dissolution adjuvant consisting of polyvinyl pyrrolidone, cyclodextrin and caffeine. CONSTITUTION:An aqueous solution agent obtained by adding 0.05-2wt/vol% compound expressed by the formula (R is 1-6C alkyl), e.g. 2-amino-7-isopropyl-5- oxo-5-[H]-benzopyrano-[2,3-b]-pyr-idine-3-carboxylic acid, etc., 0.2-20wt/vol% polyvinylpyrrolidone (25,000-120,000 average molecular weight), 0.2-5wt/vol% cyclodextrin and 0.1-2wt/vol% caffeine as a dissolution adjuvant to water. The solution agent used as nasal drip, eye drip liniment, inhalation, injection, etc. Although the above-mentioned solution agent is stable at 5-8pH, the administration to noses or eyes, etc., is preferably carried out at 7.2-7.8pH. When boric acid is used as a buffer solution, a solution of low irritancy can be obtained.
Bibliography:Application Number: JP19860193834