DURATIVE PREPARATION OF ANTIHYPERTENSIVE

PURPOSE:A specific quinazoline derivative as an antihypertensive is uniformly mixed with a polymeric base material of hydrophilic cellulose to give a durative preparation which shows an almost constant releasing behavoir and permits effective treatment by once-a-day application. CONSTITUTION:Prefera...

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Bibliographic Details
Main Authors YAGINUMA HIDEYA, KAI TOSHIYA, SHIRAISHI SUMIHIRO, TANAKA HIDEKO, TAJIRI FUMIO
Format Patent
LanguageEnglish
Published 26.05.1987
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE:A specific quinazoline derivative as an antihypertensive is uniformly mixed with a polymeric base material of hydrophilic cellulose to give a durative preparation which shows an almost constant releasing behavoir and permits effective treatment by once-a-day application. CONSTITUTION:Preferably, 4-amino-2-[ 4-bicyclo[ 2.2.2 ]oct-2-ene-5-endocarbon yl]-1-piperazinyl]-16,7-dimethoxyqui nazoline of the formula of 0.1-15wt% is mixed with a hydrophilic cellulose of 30-60wt%, synthetic aluminum silicate as a compression auxiliary of 2-10wt%, and they are subjected to compression molding to give the objective durative preparation. The hydrophilic cellulose is preferably that having a solution viscosity of 6-400cps which is measured using 2W/V% aqueous solution at 20 deg.C. The phamaceutical preparation has been made on the basis of the knowledge that the hydrophilic cellulose is very good as a polymeric base of slow release properties.
Bibliography:Application Number: JP19850255659