METHOD OF PURIFYING 2-THIOPHENEACETIC ACID

PURPOSE:To obtain the titled compound useful as a drug intermediate, etc. efficiently in high purity, by extracting crude 2-thiopheneacetic acid containing impurities by the use of a fluid in a subcritical or super critical state as an extractant. CONSTITUTION:Crude 2-thiopheneacetic acid containing...

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Bibliographic Details
Main Authors INADA SHIYOUSHICHIROU, OGASAWARA JOJI, OZAKI YOSHITAKA, TSUBAKIMOTO GIICHI
Format Patent
LanguageEnglish
Published 18.04.1986
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To obtain the titled compound useful as a drug intermediate, etc. efficiently in high purity, by extracting crude 2-thiopheneacetic acid containing impurities by the use of a fluid in a subcritical or super critical state as an extractant. CONSTITUTION:Crude 2-thiopheneacetic acid containing impurities is purified by extraction. In the operation, the purification is carried out by the use of a fluid in a subcritical or super critical state as an extractant. It is require to keep CO2 in the extraction column at 60-300kg/cm at 25-150 deg.C, preferably at 25-100 deg.C. When CO2 is used as the extractant, it has improved separating ability of 2-thiopheneacetic acid from impurities. It has merits such as treatment at relatively low temperature, simple handling and operation, economic efficiency, etc.
Bibliography:Application Number: JP19840199166