JPS6157830B

NEW MATERIAL:An amidine derivative of formula I or its acid addition salt; (R is H or alkyl; m, n are 1-3; Y is O or S; R1 is H, CN, acyl, aralkyl, acylamino, lower alkoxycarbonyl or CONH2; R2 is H, lower alkyl, lower alkenyl or lower alkynyl; or R1 and R2 may form together with the group attached t...

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Bibliographic Details
Main Authors YANAGISAWA ISAO, HIRATA YASUFUMI, ISHII YOSHIO, TAKEUCHI MASAAKI
Format Patent
LanguageEnglish
Published 09.12.1986
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:An amidine derivative of formula I or its acid addition salt; (R is H or alkyl; m, n are 1-3; Y is O or S; R1 is H, CN, acyl, aralkyl, acylamino, lower alkoxycarbonyl or CONH2; R2 is H, lower alkyl, lower alkenyl or lower alkynyl; or R1 and R2 may form together with the group attached thereto a 5- or 6-membered heterocyclic ring which may have substitution groups). EXAMPLE:N-Cyano-3-[(2-guanidinothiazol-4-yl)methylthio]propionamidine. USE:Novel, non-anticholinergic, gastric juice secretion suppressing agents. Some of the agents suppress the secretion by histamine-H2 receptor antagonistic activity. PROCESS:The objective compound I is prepared either by reacting a compound II1 with staichiometric amount of an amine III1 or by reacting a compound II2 with stoichiometric amount of a compound III2.
Bibliography:Application Number: JP19790025745