BICYCLIC PYRAZOLIDINONES

• Main Authors: SANDORA KEI SHIGUMUNDO, RUISU NIKORAUSU YUNGUHAIMU
• Format: Patent
• Language: English
• Published: 15.11.1986
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

Bicyclic pyrazolidinones which have antimicrobial and/or herbicidal properties are discussed. The use of these compounds in pharmaceutical compositions, herbicidal compositions, and methods for treating bacterial infections and controlling undesired plants is set forth. The bicyclic pyrazolidinones have the formulawherein:either R1 or R2 is hydrogen, C1 to C6 alkyl, C1 to C6 substituted alkyl, perfluoro C2 to C4 alkyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl, phenyl, substituted phenyl, nitro br cyano;a group of the formulawherein X is fluoro, chloro, bromo or iodo; a group of the formulawherein Z is 0, 1 or 2 and Rs is C1 to C6 alkyl, C1 to C6 substituted alkyl, phenyl, substituted phenyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl or a heterocyclic ring;a group of the formulawherein R6 is hydrogen, C1 to C6 alkyl, C1 to C6 substituted alkyl, perfluoro C2 to C4 alkyl, trihalomethyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl, phenyl or substituted phenyl; a group of the formulawherein R7 is hydrogen, an organic or inorganic cation, C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl, phenyl, substituted phenyl, a carboxy protecting group, or a non-toxic, metabolically-labile ester-forming group;or a group of the formulawherein R8 is hydrogen, C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 substituted alkylaryl, phenyl, or substituted phenyl;a group of the formulawherein -N≡Q is a quaternary ammonium group;or a group of the formula -CH2-S-Heterocyclic-ring and the other of R1 or R2 is a group of the formulawherein R9 is hydrogen, an organic or inorganic cation, a carboxy protecting group, or a non-toxic, metabolically-labile ester-forming group; andR3 and R4 are the same or different and are hydrogen, C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl, phenyl, substituted phenyl or a group of the formulawherein R10 has the same definition as R7; with the exception that, when R1 and R2 are a group of the formulaR3 and R4 are not methyl; or a pharmaceutically-acceptable salt thereof.