NOVEL PIPERIDINE DERIVATIVE

NEW MATERIAL:The compound of formula I [R is univalent group such as benzene, pyridine, imidazole, piperidine, morpholine, uracil, dihydrouracil, naph thalene, theophylline, indole, etc.; alk is lower alkylene, -COCH2, group of formu la II, formula III, CO, etc.; X is CO, C(OH)H, etc.; Ar is univale...

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Bibliographic Details
Main Authors SHOJI TADAO, HIGURE KUNIZO, NAKAMURA TAKAHARU, SUGIMOTO HACHIRO, SUKUMI HIROYUKI, ADACHI HIDEYUKI
Format Patent
LanguageEnglish
Published 09.10.1986
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:The compound of formula I [R is univalent group such as benzene, pyridine, imidazole, piperidine, morpholine, uracil, dihydrouracil, naph thalene, theophylline, indole, etc.; alk is lower alkylene, -COCH2, group of formu la II, formula III, CO, etc.; X is CO, C(OH)H, etc.; Ar is univalent group induced from (substituted) benzene] and its pharmacologically permissible acid addition salt. EXAMPLE:1-(2-Piperidinyl-1)-ethyl-4-(p-fluorobenzoyl)piperidine dihydrochloride. USE:Medicine having antiserotonin activity and useful for the remedy of various diseases to which the isolation of serotonin is important. PREPARATION:The compound of formula I wherein alk is lower alkyl, X is CO and Ar is substituted benzene residue can be produced e.g. by refluxing the bromoalkyl compound of formula IV and benzoylpiperidine of formula V in an organic solvent such as butanol in the presence of a base such as NaHCO3.
Bibliography:Application Number: JP19850068650