NOVEL PIPERIDINE DERIVATIVE
NEW MATERIAL:The compound of formula I [R is univalent group such as benzene, pyridine, imidazole, piperidine, morpholine, uracil, dihydrouracil, naph thalene, theophylline, indole, etc.; alk is lower alkylene, -COCH2, group of formu la II, formula III, CO, etc.; X is CO, C(OH)H, etc.; Ar is univale...
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Main Authors | , , , , , |
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Format | Patent |
Language | English |
Published |
09.10.1986
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Subjects | |
Online Access | Get full text |
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Summary: | NEW MATERIAL:The compound of formula I [R is univalent group such as benzene, pyridine, imidazole, piperidine, morpholine, uracil, dihydrouracil, naph thalene, theophylline, indole, etc.; alk is lower alkylene, -COCH2, group of formu la II, formula III, CO, etc.; X is CO, C(OH)H, etc.; Ar is univalent group induced from (substituted) benzene] and its pharmacologically permissible acid addition salt. EXAMPLE:1-(2-Piperidinyl-1)-ethyl-4-(p-fluorobenzoyl)piperidine dihydrochloride. USE:Medicine having antiserotonin activity and useful for the remedy of various diseases to which the isolation of serotonin is important. PREPARATION:The compound of formula I wherein alk is lower alkyl, X is CO and Ar is substituted benzene residue can be produced e.g. by refluxing the bromoalkyl compound of formula IV and benzoylpiperidine of formula V in an organic solvent such as butanol in the presence of a base such as NaHCO3. |
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Bibliography: | Application Number: JP19850068650 |