NOVEL ANTIBIOTIC SUBSTANCE PREPARATION

• Main Authors: KAMIYA KAZUHIRO, TORII KATSUHIRO, WATANABE ISAMU, MORI TOSHITO
• Format: Patent
• Language: English
• Published: 13.08.1986
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; DERIVATIVES THEREOF; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

NEW MATERIAL:The compound of formula I (R1 and R2 are H or CH3 and are different from each other; R3 is H, OH or OCH3; R4 is H or OH; A is amino acid or dipeptide residue; n is 1 or 2) and its salt. EXAMPLE:2''-N-L-tryptophyl-5-de-O-methyl-KA-6606 I. USE:Orally administrable antibiotic substance preparation. PREPARATION:The compound of formula I can be prepared e.g. by reacting (A) the compound of formula II (e.g. KA-6606 I) (the amino group other than 4-side chain amino group may be protected) with (B) the compound of formula HO-A-H (A is amino acid residue or dipeptide residue) (e.g. tryptophan) (the functional groups except for one carboxyl group may be protected) or its reactive derivative at the carboxyl group, and if necessary, eliminating the protective groups.